About CLOMID
Clomiphene citrate is frequently referred to by its brand names, Clomid and Omifin. Clomiphene is used to induce ovulation, to correct irregular ovulation, to help increase egg production and to correct luteal phase deficiency. It is one of the selective estrogen receptor modulators that acts as an anti-estrogen and tricks the pituitary gland into producing more FSH and LH, which, in turn, stimulates the ovary into producing more eggs and follicles. Generally, Clomid follicles are larger than injectible follicles right before ovulation.

If there is a male factor involved in your inability to get pregnant, Clomid will not fix the problem. In fact, that's why most physicians suggest a thorough exam and adequate laboratory testing before beginning Clomid. One would not want to arbitrarily begin taking Clomid if there are other problems that need to be addressed, as it would not necessarily be of any value in the face of other unrelated factors. Especially if you're paying out of pocket, unproductive overuse of the drug can get expensive.

CLOMID and Sports
For many, Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.

While it has been claimed that Clomid "stimulates" production of LH and therefore of testosterone, in fact Clomid’s activity is achieved not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen.

Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist -- the cofactor used in that tissue cannot bind and so the receptor remains inactive -- and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.

Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.

Clomid also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue. This is very significant for endurance athletes but is not very significant, if at all significant, with reasonable weight training. Clomid does not perceptibly affect gains of the weight trainer either favorably or adversely in my experience.

The drug seems to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can yield depression or PMS-like symptoms, but for most users there is no significant effect either way.

The claim that duration of intake should not exceed 10-14 days may be incorrect. Clinical studies with male patients have been for periods of a year or longer. This error probably originates from the fact that, for use in women, due to the menstrual cycle there would obviously be no point in trying to stimulate ovulation all four weeks of the month. Thus, use in women is limited to 10-14 days. That limitation is not because of toxicity.

Clomid is in fact generally regarded to be useful throughout a cycle if aromatizable drugs are being used.

CLOMID Warning!
All information regarding Clomid (clomiphene citrate) on this website is for information purposes only and is in NO WAY intended as medical advice or as a recommendation for use. NEVER use Clomid or any other medication unless under prescription and the strict guidance of a qualified health care professional.